I am a biologist specialized in lipid metabolism. I obtained a PhD on lipid metabolism in oleaginous filamentous fungi (Colin Ratledge’s laboratory, U.K.) where my work highlighted the importance of reducing power (via the malic enzyme) in the stimulation of de novo fatty acid biosynthesis. I then did postdoctoral research in the laboratory of John Ohlrogge (MSU, USA), where I studied lipid metabolism in the plant Arabidopsis thaliana. Together with other members of the group, we made several discoveries on the biosynthesis and export of cutin/suberin monomers, lipid-based polyesters that occur widely in nature and play important physiological and developmental functions. In parallel with the experimental work, I also worked with >20 lipid scientists around the world to identify, catalog, and analyze genes and proteins in lipid metabolism. The results are presented as a book chapter in the Arabidopsis Book along with an open access database (ARALIP, http://aralip.plantbiology.msu.edu/pathways/pathways), widely used and appreciated by the community.
At CEA Cadarache, I focused on the study of photosynthetic carbon metabolism in microalgae. My general objectives are to understand the molecular mechanisms of the conversion of light energy into chemical energy contained in microalgae storage compounds such as lipids and starch. In particular, we are interested in the subcellular energetics and compartmentalization that govern CO2 capture and carbon flux into fatty acids and hydrocarbons. In summary, my research focuses on microalgae metabolism, physiology and biotechnology in the context of bioenergy and the circular carbon economy.